We tested whether genetic variants in the ercc1 gene are associated with susceptibility to lung cancer and efficacy of platinumchemotherapy in patients with small cell lung cancer sclc. Prognostic and predictive role of excision repair cross. Excision repair crosscomplementation group 1 is a prognostic. This study aims to investigate the role of ercc1 as a predictive and prognostic marker in colorectal patients receiving oxaliplatin based chemotherapy and chemoradiation. Excisionrepair crosscomplementing, complementation group. Ercc3 excision repair crosscomplementing rodent repair. The excision repair crosscomplementation group 1 ercc1 enzyme is a wellknown key mediator of the cisplatin resistance mechanism in non smallcell lung cancer 9 x 9 olaussen, k. Together with ercc4, ercc1 forms the ercc1xpf enzyme complex that participates in dna repair and dna recombination. Ercc6 is defined as excisionrepair crosscomplementing, complementation group 6 rarely. Ercc8 excision repair crosscomplementing rodent repair deficiency, complementation group 8, authors. No association of ercc1 c8092a and t19007c polymorphisms. Excision repair cross complementation group 1 ercc1 is a chief component of the ner pathway 5,6 and a highly conserved protein, essential for elimination of dna adducts caused by the platinum compound. The human excision repair crosscomplementation group 1 ercc1. As a consequence, ercc1 mediates resistance to mitomycin c mmc and platinum chemotherapeutic agents and may predict treatment failure.
Mar 05, 2016 excision repair cross complementation group 1 is a prognostic biomarker in patients with colorectal cancer receiving chemotherapy article pdf available in chinese medical journal 1295. Excision repair cross complementation group 1 is a. Using immunohistochemistry in resected tumors from patients included in the international adjuvant lung cancer trial, the study of important biomarkers. Epidermal growth factor receptor, excisionrepair cross. Association studies of excision repair crosscomplementation. Dna repair by ercc1 in nonsmallcell lung cancer and cisplatinbased adjuvant chemotherapy. Excision repair definition of excision repair by medical. Citeseerx excision repair crosscomplementation group 1. Dna excision repair protein ercc1 is a protein that in humans is encoded by the ercc1 gene.
Ercc1 and histopathology in advanced nsclc patients. Background recently, several studies observed that locally advanced cervical carcinoma with negative excision repair crross complementation group one enzyme expression has better outcomes in cisplatinbased chemotherapy or chemoradiotherapy than carcinoma with positive excission repair cross complementation group one enzyme expression. Ercc2 excision repair crosscomplementing rodent repair. However, no validated clinical or biologic predictor of response to this chemotherapy has been identified to date. Excision repair crosscomplementation group 1 polymorphism. Association between excision repair crosscomplementation. Expression of excision repair crosscomplementation group 1 and class iii. Human cancer biology clinical cancer research regulation. Ercc1 ercc excision repair 1, endonuclease noncatalytic. Ercc excision repair 1, endonuclease noncatalytic subunit.
Pdf excision repair cross complementation group 1 is a. All statistical testing was twosided and used sas software version 8 cary, nc. Expression of excision repair crosscomplementation group 1 ercc1 is correlated with a favourable prognosis in patients who have undergone surgical resection of nonsmall cell lung cancer. Ercc8 excision repair crosscomplementing rodent repair. Excision repair crosscomplementation group one enzyme protein has a. Excision repair crosscomplementation group 1 ercc1 is an excision nuclease that works in the repairosome responsible for excision of the covalent bulky damage to the dna, the ratelimiting step in the ner process 26, 27. To study the nuclear organization and dynamics of nucleotide excision repair ner, the endonuclease ercc1xpf for excision repair cross complementation group 1 xeroderma pigmentosum group f was tagged with green fluorescent protein and its mobility was monitored in living chinese hamster ovary cells. Excision repair crosscomplementation group 1 ercc1 is widely recognized as a powerful component of nucleotide excision repair ner pathway, which not only involves the repair of interstrand crosslinks in the dna but also involves the recognition and remove of cytotoxic agents like platinum.
Ercc4 is a protein designated as dna repair endonuclease xpf that in humans is encoded by the ercc4 gene. Ercc1 plays a key role in nucleotide excision repair and in removing platinuminduced dna adducts. Excision repair crosscomplementation group 1 ercc1xeroderma pigmentosum group f xpf protein complex plays key roles in several dna repair pathways, particularly in those involved in the repair of ultravioletinduced lesions and intrastrand or interstrand cross links 10. Excision repair cross complementation group 1 is a chemotherapy. Together with ercc1, ercc4 forms the ercc1xpf enzyme complex that participates in dna repair and dna recombination the nuclease enzyme ercc1xpf cuts specific structures of dna. Diagnostic and prognostic values of the mrna expression of excision repair crosscomplementation enzymes in hepatitis b virusrelated hepatocellular carcinoma lu yang, 1, ming xu,2, chuanbao cui, 1 penghai wei, 1 shuzhi wu, 1 zuojie cen, 1 xingxing meng, 1 qiongguang huang, 1 zhichun xie1 1department of epidemiology, guangxi medical university, nanning 530021, guangxi zhuang autonomous. Association between excision repair crosscomplementation group 1 polymorphism and clinical outcome of platinumbased chemotherapy in patients with epithelial. There are conflicting opinions toward the impaction of elevated ercc1 expression on tumor progression. This enzyme plays a ratelimiting role in the nucleotide excision repair pathway that recognizes and removes cisplatininduced dna adducts 10, 11. Mutations cause cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Ercc6 stands for excisionrepair crosscomplementing, complementation group 6. Excision repair crosscomplementation group 1 how is.
May 23, 2007 ercc1 excision repair cross complementation group 1 is a subunit of the nucleotide excision repair complex, which can perform dna strand incision correction of dna damage. In this metaanalysis, we quantitatively evaluated the. Association studies of excision repair crosscomplementation group. There are conflicting opinions toward the impaction of elevated ercc1 expression on tumor.
Excision repair cross complementation group 1 and thymidylate synthase expression in patients with mesothelioma. Prognostic value of excision repair crosscomplementing mrna. The prognostic value of excission repair crosscomplementation. Kweekel b 1 xiaobo lu b kees franken c miriam koopman d 2 hans gelderblom a ninja f. Excision repair crosscomplementation group 1 ercc1 is a key component in dna repair mechanisms and may influence the tumor dnatargeting effect of the chemotherapeutic agent oxaliplatin. Excision repair crosscomplementation group 1 ercc1 status and lung cancer outcomes.
Excision repair cross complementing rodent repair deficiency, complementation group 5 xeroderma pigmentosum, complementation group g is involved in excision repair of uvinduced dna damage. High ercc1 expression was associated with worse diseasefree survival in uterine cervical adenocarcinoma patients who received adjuvant cisplatinbased chemotherapy or chemoradiotherapy with cisplatin. Epub ahead of print prognostic and predictive role of excision repair crosscomplementation group 1 and thymidylate synthase in colorectal carcinoma patients received folfox chemotherapy. Correlation analysis and prognostic impact of 18ffdg pet. Except for excision repair crosscomplementing 1 ercc1, mrna. We performed the present metaanalysis to better elucidate this issue in advanced hnscc. The enzyme plays a key role in nucleotide excision repair ner pathway. Atpdependent helicase ercc6like, dna excision repair protein ercc6like, plk1interacting checkpoint helicase, snf2rad54 family protein, excision repair crosscomplementing rodent repair deficiency complementation group 6 like, excision repair protein ercc6like, tumor antigen bjhcc15, excision repair crosscomplementing rodent. Dna repair capacity of ner pathway can be represented by the expression level of excision repair crosscomplementation group 1 ercc1 which is one of the most important members of the pathway. Ercc3 excision repair crosscomplementing rodent repair deficiency, complementation group 3, authors. To describe the expression of tissue epidermal growth factor receptor egfr, excisionrepair crosscomplementation group 1 protein ercc1, and thymidylate synthase ts in patients with penile cancer and explore their association with stage and outcome.
This study aims to investigate the role of ercc1 as a predictive and prognostic marker in. A gynecologic oncology group study of platinumdna adducts. Many reports have explored the role of the excision repair crosscomplementation group 1 enzyme ercc1 expression in the repair mechanism of cisplatininduced dna adducts in cancer cells. Thymidylate synthase but not excision repair crosscomplementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexedbased chemotherapy luisella righi, mauro g. Excision repair crosscomplementation group 1 ercc1 protein forms a heterodimer with xpf that cleaves the dna 5. Due to its role in dna repair in association with the other ercc proteins. The previous studies have shown that the highly expressed ercc1 is related to the poor prognosis of various tumors. Data show that excision repair crosscomplementation group 1 ercc1 rs11615 and rs3212986 polymorphisms were associated with poor response to chemotherapy and shorter survival time of advanced nonsmall cell lung cancer nsclc. The aim of the present study was to assess the prognostic role of dna repair markers, such as excision repair crosscomplementation group 1 and ribonucleotide reductase m1, in multimodally treated patients with malignant pleural mesothelioma. The excision repair crosscomplementation group 1 ercc1 enzyme is a wellknown key mediator of the cisplatin resistance mechanism in non smallcell lung cancer 9. Thymidine synthase, thymidine phosphorylase, and excision repair crosscomplementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as firstline treatment for patients with advanced oesophageal squamous cell carcinoma. A metaanalysis of published studies and recommendations richard a.
The excision repair crosscomplementation group 1 ercc1, combined with xeroderma pigmentsum group f 5, 6, acting as a heterodimeric, structurespecific endonuclease, plays a ratelimiting role in nucleotide excision repair by catalyzing the incision on the 5. How is excisionrepair crosscomplementing, complementation group 6 abbreviated. Excision repair crosscomplementation group 1 ercc1 encodes an enzyme that is essential for the efficient repair of dna damage induced by platinum compounds including oxaliplatin. Excision repair crosscomplementation group 1 ercc1 is the lead enzyme. Ercc1 excision repair cross complementation group 1 is a subunit of the nucleotide excision repair complex, which can perform dna strand incision correction of. Regulation of excision repair crosscomplementation group. Ercc2 excision repair crosscomplementing rodent repair deficiency, complementation group 2, authors. We examined the association between two polymorphisms of ercc1, codon 118 ct and. Browse our excision repair crosscomplementing rodent. Enhanced cisplatin resistance in oralcancer stemlike cells. The ercc1 gene and its putative association with human ageing. It is excisionrepair crosscomplementing, complementation group 6. Dna repair is a critical mechanism of resistance to platinumbased chemotherapy.
Expression of excision repair crosscomplementation group 1. Expression of excision repair crosscomplementation group. Action of dna repair endonuclease ercc1xpf in living cells. The excision repair crosscomplementation group 1 ercc1 is a dna damage repair gene of the nucleotide excision repair pathway, which removes cisplatininduced dna adducts. Pdf excision repair cross complementation group 1 and. We examined the association between two polymorphisms of ercc1, codon 118 ct and c8092a, which are. May 12, 2014 excision repair cross complementation group 1 ercc1 is a key component of homologous recombinationbased repair of interstrand dna crosslinks icls. Background recently, several studies observed that locally advanced cervical carcinoma with negative excision repair crrosscomplementation group one enzyme expression has better outcomes in cisplatinbased chemotherapy or chemoradiotherapy than carcinoma with positive excission repair crosscomplementation group one enzyme expression.
Emodin regulating excision repair crosscomplementation. Expression of ribonucleoside reductase subunit m1, but not. Precise localization of the excision repair gene, ercc5, to human chromosome q32. Wikigenes ercc3 excision repair crosscomplementation group 3. Excision repair crosscomplementation group 1 ercc1 status. Excision repair crosscomplementation group 1 protein ercc1 forms a heterodimer with xpf that cleaves the dna 5. Wikigenes ercc1 excision repair crosscomplementation. Dna repair machinery responsible for nucleotide excision repair. Enzyme repair crosscomplementation group 1 ercc1, which is among the most promising predictive markers, has not only been explored in nsclc but also in ovarian cancer 4, 5, gastric cancer and colorectal cancer 7, 8. It plays a major role in better repair and tolerance of dna damage, leading to resistance of platinum drugs. On this basis, several commercial laboratories have offered ercc1 testing to facilitate clinical decision making, but the reliability of such assays has recently been.
Among these four mechanisms, induction of the dna repair protein excision repair crosscomplementation group 1 ercc1 has been regarded as one of the most important factors controlling cisplatin resistance. Excision repair crosscomplementation group 1 ercc1 is the lead enzyme in the nucleotide excision repair process. Clinical response to mmc or cisplatin cddpbased radiochemotherapy rct was assessed in 106 head and. Excision repair crosscomplementation group 1 polymorphism predicts overall survival in advanced nonsmall cell lung cancer patients treated. The authors evaluated whether ercc1, p53, or trx expression could predict progression. Original article emodin regulating excision repair crosscomplementation group 1 through fibroblast growth factor receptor 2 signaling gang chen, hong qiu. Importance of excision repair crosscomplementation group 1. Platinumbased neoadjuvant chemotherapy for locally advanced cervical cancer has some benefits for patients responding to chemotherapy. Many aspects of these two gene products are described together here because they are partners during dna repair.
The prognostic and predictive value of excision repair. The excision repair crosscomplementation group 1 ercc1, a dna repair protein, can correct damages to dna molecules caused by chemotherapy or radiotherapy. Excision repair crosscomplementation group 1 ercc1 status and. Excision repair crosscomplementation group 1 ercc1. Ercc1 excision repair crosscomplementation group 1. Excision repair crosscomplementing rodent repair deficiency, complementation group 1 imported automatic assertion inferred from database entries i embl. The aim of this study was to determine the prognostic and predictive values of ribonucleoside reductase subunit m1 rrm1 and excision repair cross. Characterization of functional excision repair cross. To retrospectively analyze the expression of excision repair crosscomplementation group 1 ercc1 and. Cell cycle association and hypoxia regulation of excision. Ercc1 expression in patients with colorectal cancer.
Ercc8 ercc excision repair 8, csa ubiquitin ligase complex subunit the function of ercc8 substraterecognition component of the csa complex, a dcx ddb1cul4xbox e3 ubiquitinprotein ligase complex, involved in transcriptioncoupled nucleotide excision repair. Is excision repair crosscomplementation group1 expression a. Commercial laboratory testing of excision repair cross. The general transcription repair factor tfiih is recruited to the excision repair complex by the xpa protein independent of the tfiie transcription factor. The excision repair crosscomplementation group 1 ercc1 plays a pivotal role in dna repair and has been linked to protection against carcinogenesis and resistance to platinumbased anticancer drugs. Thymidine synthase, thymidine phosphorylase, and excision. Excision repair cross complementation group one or excission repair cross complementation group one enzyme, and chemoradiotherapy or chemoradiation or radiochemotherapy or chemotherapy or radiotherapy or radiation or electromagnetic radiation. Dna can be damaged by ultraviolet uv rays from the sun and by toxic chemicals, radiation, and unstable molecules called free radicals. Increased ercc1 mrna levels are related directly to platinum resistance in various cancers. Excision repair crosscomplementation group 1 ercc1 c118t snp does not affect cellular response to oxaliplatin author links open overlay panel lieke h. Pdf ercc1 excision repair crosscomplementation group 1. Excision repair crosscomplementation group 1 protein functions within the repair complex as it heterodimers with the xeroderma pigmentosum complementation group f xpf protein and functions as an endonuclease producing a 5. Survival and response to platinumbased induction chemotherapy are heterogeneous among patients with malignant pleural mesothelioma.
Recent reports have suggested that ercc1 is a predictive and prognostic marker in solid cancers treated with platinum. Excisionrepair crosscomplementing, complementation group 6. Wikigenes ercc5 excision repair crosscomplementation group 5. Thymidylate synthase but not excision repair cross. No association of ercc1 c8092a and t19007c polymorphisms to. Wikigenes ercc5 excision repair crosscomplementation. Only those studies published from 1990 to 31 may 2018 in english were considered. The ercc8 gene provides instructions for making a protein called cockayne syndrome a csa, which is involved in repairing damaged dna. To study the nuclear organization and dynamics of nucleotide excision repair ner, the endonuclease ercc1xpf for excision repair cross complementation group 1 xeroderma pigmentosum group f was tagged with green fluorescent protein and its mobility was monitored in. Excision repair crosscomplementation group 1 ercc1 protein has been extensively investigated as a prognostic and predictive factor for platinumbased treatment in head and neck squamous cell carcinoma hnscc but with inconsistent results. The activation of phosphatidylinositol 3kinase pi3kprotein kinase b aktmammalian target of rapamycin mtor signaling and upregulation of excision repair cross complementation group 1 ercc1 are the two most important factors that confer resistance to cisplatin ddp therapy in nonsmallcell lung cancer nsclc. Excision repair crosscomplementation group 1, the structurespecific dna repair endonuclease responsible for 5.
The present study aims to investigate the role of polymorphisms in dna repair genes, excision repair cross. This enzyme plays a ratelimiting role in the nucleotide excision repair pathway that recognizes and. Excision repairs cross complementation group1 ercc1 gene plays a ratelimiting role in nucleotide excision repair ner mechanisms that repair dna cross linking among chains. Aug 10, 2010 our purpose was to evaluate thymidine synthase ts, thymidine phosphorylase tp, and excision repair crosscomplementation group 1 ercc1 expression as biomarkers for capecitabine and cisplatin. High dna repair capacity of ner pathway certainly contributes greatly to drug resistance in the platinumbased chemotherapy of nsclc.
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